Oocyte aging has a significant impact on reproductive outcomes both quantitatively and
qualitatively. However, the molecular mechanisms underlying the age-related decline in …

Telomeres mediate biologic aging in organisms as diverse as plants, yeast, and mammals.
We propose a telomere theory of reproductive aging that posits telomere shortening in the …

Reproductive aging is on the rise globally and inseparable from the entire aging process. An
extreme form of reproductive aging is premature ovarian insufficiency (POI), which to date …

Background Telomeres have an essential role in maintaining the integrity and stability of the
human chromosomal genome and preserving essential DNA biological functions. Several …

Ovarian infertility and subfertility presenting with premature ovarian insufficiency (POI) and
diminished ovarian reserve are major issues facing the developed world due to the trend of …

Purpose Ovarian aging is closely tied to the decline in ovarian follicular reserve and oocyte
quality. During the prolonged reproductive lifespan of the female, granulosa cells connected …

Genomic instability is widespread during early embryo development. Aneuploidy,
mosaicism, and copy number variants (CNVs) commonly appear in human preimplantation …

Reproductive aging is a natural process conserved across species and is well-known in
females. It shows age-related follicle depletion and reduction of oocyte quality, eventually …

Current social trends of delayed reproduction to the fourth and fifth decade of life call for a
better understanding of reproductive aging. Demographic studies correlated late …

Implantation rate decreases and miscarriage rate increases with advancing maternal age.
The oocyte must be the locus of reproductive aging because donation of oocytes from …