The vagus nerve represents the main component of the parasympathetic nervous system,
which oversees a vast array of crucial bodily functions, including control of mood, immune …

The number of publications investigating heart rate variability (HRV) in psychiatry and the
behavioral sciences has increased markedly in the last decade. In addition to the significant …

Background Deep brain stimulation (DBS) of the subcallosal cingulate white matter has
shown promise as an intervention for patients with chronic, unremitting depression. To test …

The vagus nerve is a major component of the autonomic nervous system, has an important
role in the regulation of metabolic homeostasis, and plays a key role in the neuro-endocrine …

Context Deep brain stimulation (DBS) may be an effective intervention for treatment-resistant
depression (TRD), but available data are limited. Objective To assess the efficacy and safety …

Depression is characterized by disturbed sleep and eating, a variety of other nonspecific
somatic symptoms, and significant somatic comorbidities. Why there is such close …

The vagus nerve, the great wanderer, is involved in numerous processes throughout the
body and vagus nerve stimulation (VNS) has the potential to modulate many of these …

Although the preceding chapters discuss much of the new knowledge of neurocircuitry of
neuropsychiatric diseases, and an invasive approach to treatment, this chapter describes …

Major depressive disorder (MDD) is a common mood disorder that can result in significant
discomfort as well as interpersonal and functional disability. A growing body of research …

Major depressive disorder (MDD) is prevalent. Although standards antidepressants are
more effective than placebo, up to 35% of patients do not respond to 4 or more conventional …