T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …

Next-generation vaccines that utilize T cells could potentially overcome the limitations of
current influenza vaccines that rely on antibodies to provide narrow subtype-specific …

Neoantigens play a key role in the recognition of tumour cells by T cells; however, only a
small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which …

An improved understanding of human T cell-mediated immunity in COVID-19 is important for
optimizing therapeutic and vaccine strategies. Experience with influenza shows that …

To better understand primary and recall T cell responses during coronavirus disease 2019
(COVID-19), it is important to examine unmanipulated severe acute respiratory syndrome …

Abstract Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and
infect humans, with IAV and IBV causing the most severe disease. CD8+ T cells confer cross …

The human lung harbors a large population of resident memory T cells (Trm cells). These
cells are perfectly positioned to mediate rapid protection against respiratory pathogens such …

CD8+ T cells provide robust antiviral immunity, but how epitope-specific T cells evolve
across the human lifespan is unclear. Here we defined CD8+ T cell immunity directed at the …

Purpose: Cancer antigen–specific T cells are key components in antitumor immune
response, yet their identification in the tumor microenvironment remains challenging, as …

Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we
show circulating CD8+ T-cell profiles from patients hospitalized with avian H7N9, seasonal …