Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that
comprise around 10% of all soft tissue sarcomas and develop in about 8–13% of patients …

Malignant peripheral nerve sheath tumor (MPNST) is the leading cause of mortality in
patients with neurofibromatosis type 1. In 2002, an MPNST consensus statement reviewed …

Abstract Neurofibromatosis Type 1 (NF1) is a genetic disease caused by mutations in
Neurofibromin 1 (NF1). NF1 patients present with a variety of clinical manifestations and are …

Genetic changes required for the formation and progression of human Schwann cell tumors
remain elusive. Using a Sleeping Beauty forward genetic screen, we identified several …

Neurofibromas, which are benign Schwann cell tumors, are the hallmark feature in the
autosomal dominant condition neurofibromatosis 1 (NF1) and are associated with biallelic …

Therapeutic options are limited for neurofibromatosis type 1 (NF1)-associated malignant
peripheral nerve sheath tumors (MPNST) and clinical trials using drug agents have so far …

Sarcomas represent one of the most challenging tumor types to treat due to their diverse
nature and our incomplete understanding of their underlying biology. Recent work suggests …

Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that occur
spontaneously, or from benign plexiform neurofibromas, in the context of the genetic …

Neurofibromatosis Type 1 (NF1) is a common genetic disorder and cancer predisposition
syndrome (1: 3000 births) caused by mutations in the tumor suppressor gene NF1. NF1 …

Comprehensive genomic analyses of common nervous system cancers provide new
insights into their pathogenesis, diagnosis, and treatment. Although analogous studies of …