Recent advances in transition-metal-catalyzed carbene insertion to C–H bonds

Y He, Z Huang, K Wu, J Ma, YG Zhou… - Chemical Society Reviews, 2022 - pubs.rsc.org
C–H functionalization has been emerging as a powerful method to establish carbon–carbon
and carbon–heteroatom bonds. Many efforts have been devoted to transition-metal …

Modern organic synthesis with α-diazocarbonyl compounds

A Ford, H Miel, A Ring, CN Slattery, AR Maguire… - Chemical …, 2015 - ACS Publications
In 1994, Ye and McKervey published a paper in Chemical Reviews entitled “Organic
Synthesis with α-Diazocarbonyl Compounds”. 1 Our intention then was to draw attention to …

Late-stage diversification of indole skeletons through nitrogen atom insertion

JC Reisenbauer, O Green, A Franchino, P Finkelstein… - Science, 2022 - science.org
Compared with peripheral late-stage transformations mainly focusing on carbon–hydrogen
functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead …

Cobalt-Catalyzed Enantioselective C–H Annulation of Benzylamines with Alkynes: Application to the Modular and Asymmetric Syntheses of Bioactive Molecules

YJ Wu, JH Chen, MY Teng, X Li, TY Jiang… - Journal of the …, 2023 - ACS Publications
The transition metal-catalyzed enantioselective C–H functionalization strategy has
revolutionized the logic of natural product synthesis. However, previous applications have …

C H Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

J Yamaguchi, AD Yamaguchi… - Angewandte Chemie …, 2012 - Wiley Online Library
The direct functionalization of C H bonds in organic compounds has recently emerged as a
powerful and ideal method for the formation of carbon–carbon and carbon–heteroatom …

Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation

L McMurray, F O'Hara, MJ Gaunt - Chemical Society Reviews, 2011 - pubs.rsc.org
Metal-catalysed C–H bond functionalisation has had a significant impact on how chemists
make molecules. Translating the methodological developments to their use in the assembly …

Funktionalisierung von C‐H‐Bindungen: neue Synthesemethoden für Naturstoffe und Pharmazeutika

J Yamaguchi, AD Yamaguchi, K Itami - Angewandte Chemie, 2012 - Wiley Online Library
Die direkte Funktionalisierung von C‐H‐Bindungen in organischen Molekülen hat sich in
jüngster Zeit zu einer wirksamen und idealen Methode entwickelt, mit der Kohlenstoff …

Application of donor/acceptor-carbenoids to the synthesis of natural products

HML Davies, JR Denton - Chemical Society Reviews, 2009 - pubs.rsc.org
The metal catalyzed reactions of diazo compounds have been broadly used in organic
synthesis. The resulting metal–carbenoid intermediates are capable of undergoing a range …

Fluorination patterning: a study of structural motifs that impact physicochemical properties of relevance to drug discovery

QA Huchet, B Kuhn, B Wagner… - Journal of medicinal …, 2015 - ACS Publications
The synthesis of a collection of 3-substituted indole derivatives incorporating partially
fluorinated n-propyl and n-butyl groups is described along with an in-depth study of the …

Advancement in Cascade [1,n]‐Hydrogen Transfer/Cyclization: A Method for Direct Functionalization of Inactive C(sp3)H Bonds

L Wang, J Xiao - Advanced Synthesis & Catalysis, 2014 - Wiley Online Library
Abstract The cascade [1, n]‐hydrogen transfer/cyclization, recognized one century ago, has
received considerable interest in recent decades and great achievements have been made …