Pulmonary hypertension: a contemporary review

S Johnson, N Sommer, K Cox-Flaherty… - American journal of …, 2023 - atsjournals.org
Major advances in pulmonary arterial hypertension, pulmonary hypertension (PH)
associated with lung disease, and chronic thromboembolic PH cast new light on the …

Right heart failure in left heart disease: imaging, functional, and biochemical aspects of right ventricular dysfunction

S Ghio, M Acquaro, P Agostoni, G Ambrosio… - Heart Failure …, 2023 - Springer
For decades, cardiologists have largely underestimated the role of the right heart in heart
failure due to left heart disease. Nowadays, the importance of evaluating right ventricular …

Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension

F Khassafi, P Chelladurai, C Valasarajan… - Nature cardiovascular …, 2023 - nature.com
Right ventricular (RV) function is critical to prognosis in all forms of pulmonary hypertension.
Here we perform molecular phenotyping of RV remodeling by transcriptome analysis of RV …

Pathophysiology of the right ventricle and its pulmonary vascular interaction

AR Hemnes, DS Celermajer, M D'Alto… - European …, 2024 - publications.ersnet.org
The right ventricle and its stress response is perhaps the most important arbiter of survival in
patients with pulmonary hypertension of many causes. The physiology of the …

A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis

H Port, CM Hausgaard, Y He, WP Maksymowych… - Scientific Reports, 2023 - nature.com
Rheumatic joints have an altered cartilage turnover. Cartilage intermediate layer protein 1
(CILP-1) is secreted from articular chondrocytes and deposited into the cartilage …

Exploring functional differences between the right and left ventricles to better understand right ventricular dysfunction

J Bernal-Ramirez, MC Díaz-Vesga… - Oxidative Medicine …, 2021 - Wiley Online Library
The right and left ventricles have traditionally been studied as individual entities.
Furthermore, modifications found in diseased left ventricles are assumed to influence on …

New progress in diagnosis and treatment of pulmonary arterial hypertension

Z Zhang, S Zhu, M Wang, X Wang, X Tong… - Journal of …, 2022 - Springer
Pulmonary arterial hypertension (PAH) is a progressive disease. Although great progress
has been made in its diagnosis and treatment in recent years, its mortality rate is still very …

Metabolic changes contribute to maladaptive right ventricular hypertrophy in pulmonary hypertension beyond pressure overload: an integrative imaging and omics …

I García-Lunar, I Jorge, J Sáiz, N Solanes… - Basic Research in …, 2024 - Springer
Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary
hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload …

CILP-1 is a biomarker for backward failure and right ventricular dysfunction in HFrEF

A Weidenhammer, S Prausmüller, C Partsch, G Spinka… - Cells, 2023 - mdpi.com
Background: CILP-1 regulates myocardial fibrotic response and remodeling and was
reported to indicate right ventricular dysfunction (RVD) in pulmonary hypertension (PH) and …

Fibroblast growth factor 23 as a biomarker of right ventricular dysfunction in pulmonary hypertension

L Widmann, S Keranov, L Jafari, C Liebetrau… - Clinical Research in …, 2023 - Springer
Background Fibroblast growth factor 23 (FGF-23) has been associated with left ventricular
hypertrophy (LVH) and heart failure. However, its role in right ventricular (RV) remodeling …