Exosomes generated from iPSC-derivatives: new direction for stem cell therapy in human heart diseases

JH Jung, X Fu, PC Yang - Circulation research, 2017 - Am Heart Assoc
Cardiovascular disease (CVD) is the leading cause of death in modern society. The adult
heart innately lacks the capacity to repair and regenerate the damaged myocardium from …

Immunoregulatory effects of stem cell-derived extracellular vesicles on immune cells

M Xie, W Xiong, Z She, Z Wen, AS Abdirahman… - Frontiers in …, 2020 - frontiersin.org
Recent investigations on the regulatory action of extracellular vesicles (EVs) on immune
cells in vitro and in vivo have sparked interest on the subject. As commonly known, EVs are …

Induced pluripotent stem cell (iPSC)–derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs

M Adamiak, G Cheng, S Bobis-Wozowicz… - Circulation …, 2018 - Am Heart Assoc
Rationale: Extracellular vesicles (EVs) are tiny membrane-enclosed droplets released by
cells through membrane budding or exocytosis. The myocardial reparative abilities of EVs …

[HTML][HTML] Neutrophil-derived trail is a proinflammatory subtype of neutrophil-derived extracellular vesicles

YJ Youn, S Shrestha, YB Lee, JK Kim, JH Lee, K Hur… - Theranostics, 2021 - ncbi.nlm.nih.gov
Aims: Extracellular vesicles (EVs) are membrane-derived vesicles that mediate intercellular
communications. Neutrophils produce different subtypes of EVs during inflammatory …

Bio-inspired nanocarriers derived from stem cells and their extracellular vesicles for targeted drug delivery

M Abudurexiti, Y Zhao, X Wang, L Han, T Liu, C Wang… - Pharmaceutics, 2023 - mdpi.com
With their seemingly limitless capacity for self-improvement, stem cells have a wide range of
potential uses in the medical field. Stem-cell-secreted extracellular vesicles (EVs), as …

Flow virometry as a tool to study viruses

JLR Zamora, HC Aguilar - Methods, 2018 - Elsevier
In the last few decades, flow cytometry has redefined the field of biology, exponentially
enhancing our understanding of cells, immunology, and microbiology. Flow cytometry …

Potential therapies by stem cell‐derived exosomes in CNS diseases: Focusing on the neurogenic niche

A Luarte, LF Bátiz, U Wyneken… - Stem cells …, 2016 - Wiley Online Library
Neurodegenerative disorders are one of the leading causes of death and disability and one
of the biggest burdens on health care systems. Novel approaches using various types of …

Extracellular vesicles from organoid‐derived human retinal progenitor cells prevent lipid overload‐induced retinal pigment epithelium injury by regulating fatty acid …

H Gao, Y Zeng, X Huang, Q Liang, J Xie… - Journal of …, 2024 - Wiley Online Library
Retinal degeneration (RD), a group of diseases leading to irreversible vision loss, is
characterised by retinal pigment epithelium (RPE) or retinal neuron damage and loss. With …

Cartilage tissue engineering by co-transplantation of chondrocyte extracellular vesicles and mesenchymal stem cells, entrapped in chitosan–hyaluronic acid hydrogel

A Heirani-Tabasi, S Hosseinzadeh… - Biomedical …, 2021 - iopscience.iop.org
Mesenchymal stem cells (MSCs) on injectable hydrogels are mostly used to regenerate
articular cartilage, which would have a variety of outcomes. Chondrocyte extracellular …

Considerations and implications in the purification of extracellular vesicles–a cautionary tale

YXF Lee, H Johansson, MJA Wood… - Frontiers in …, 2019 - frontiersin.org
Extracellular vesicles (EVs) are nano-sized particles constitutively released from cells into all
biological fluids. Interestingly, these vesicles contain genetic cargoes including proteins …