Nature is the most abundant source for novel drug discovery. Lycorine is a natural alkaloid
with immense therapeutic potential. Lycorine is active in a very low concentration and with …

The amaryllidaceae family consists of about 75 genera and 1100 species that are wide-
spread in the tropics and warm temperate regions of the world. Since the first isolation of …

SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug
development. In this study, we present an antiviral screening strategy involving a novel in …

Hematopoietic stem and progenitor cells (HSPCs) can reconstitute and sustain the entire
blood system. We generated a highly specific transgenic reporter of HSPCs in zebrafish …

The COVID-19, caused by SARS-CoV-2, is threatening public health, and there is no
effective treatment. In this study, we have implemented a multi-targeted anti-viral drug …

Nanoparticles containing high-Z elements are known to boost the efficacy of radiation
therapy. Gadolinium (Gd) is particularly attractive because this element is also a positive …

The immense chemical diversity of plant-derived secondary metabolites coupled with their
vast array of biological functions has seen this group of compounds attract considerable …

Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial
plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of …

The alkaloids characteristically produced by the subfamily Amaryllidoideae of the
Amaryllidaceae, bulbous plant species that include well know genera such as Narcissus …

The severe anticancer situation as well as the emergence of multidrug-resistant (MDR)
cancer cells has created an urgent need for the development of novel anticancer drugs with …