MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that environmental influences during early development affect the risk of later pathophysiological …
Obesity has reached epidemic proportions and pregnancies in obese mothers have increased risk for complications including gestational diabetes, hypertensive disorders …
Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …
Research involving nonhuman primates (NHPs) has played a vital role in many of the medical and scientific advances of the past century. NHPs are used because of their …
Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments …
Accumulating evidence suggests that insults occurring during the perinatal period alter the developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …
CE McCurdy, JM Bishop, SM Williams… - The Journal of …, 2009 - Am Soc Clin Investig
Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic diseases; however, the mechanism (s) whereby excess maternal nutrition affects fetal …
A Gabory, TJ Roseboom, T Moore, LG Moore… - Biology of sex …, 2013 - Springer
Sex differences occur in most non-communicable diseases, including metabolic diseases, hypertension, cardiovascular disease, psychiatric and neurological disorders and cancer. In …
Although the large data sets combining birth and placental weights, maternal and postnatal nutrition, and health records are sparse for food animals, many controlled studies have …