Background: Among gram-negative bacteria, Klebsiella pneumoniae is one of the most
common causes of healthcare-related infection. Bloodstream infections (BSIs) caused by …

Pseudomonas aeruginosa is a Gram-negative human pathogen with extensively drug-
resistant (XDR) strains emerging in hospitals across the globe. This systematic review is …

Importance Broad-spectrum antibiotics are recommended for all patients with suspected
sepsis to minimize the risk of undertreatment. However, little is known regarding the net …

Background Reports that septic shock incidence is rising and mortality rates declining may
be confounded by improving recognition of sepsis and changing coding practices. We …

Background. Shock frequently complicates necrotizing fasciitis (NF) caused by group A
Streptococcus (GAS) or Staphylococcus aureus. Intravenous immunoglobulin (IVIG) is …

Polymyxins are relied upon for the treatment of carbapenem-resistant Gram-negative
bacterial infections, but polymyxin resistance is increasing. Only broth microdilution is …

Background Ceftazidime-avibactam has in vitro activity against some carbapenem-resistant
gram-negative infections (GNIs), and therefore may be a useful alternative to more toxic …

Purpose The rising incidence of carbapenem-resistant Pseudomonas aeruginosa (PA)
bloodstream infection (BSI) has made the selection of antibiotic therapy more difficult and …

According to the Centers for Disease Control and Prevention, 2.8 million antibiotic-resistant
infections occur in the United States each year, and 35 000 people die from these infections …

Background Mortality after smoke inhalation–associated acute lung injury (SI-ALI) remains
substantial. Age and burn surface area are risk factors of mortality, whereas the impact of …