[HTML][HTML] Hallmarks of aging: An expanding universe
Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
Meta-hallmarks of aging and cancer
Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
Age-related immune alterations and cerebrovascular inflammation
CE Finger, I Moreno-Gonzalez, A Gutierrez… - Molecular …, 2022 - nature.com
Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …
development of many age-related diseases, including vascular disease. The world's …
A new clinical age of aging research
Aging is a major risk factor for a variety of diseases, thus, translation of aging research into
practical applications is driven by the unmet need for existing clinical therapeutic options …
practical applications is driven by the unmet need for existing clinical therapeutic options …
The pathobiology of neurovascular aging
MM Santisteban, C Iadecola - Neuron, 2025 - cell.com
As global life expectancy increases, age-related brain diseases such as stroke and
dementia have become leading causes of death and disability. The aging of the …
dementia have become leading causes of death and disability. The aging of the …
[HTML][HTML] The quest for eternal youth: hallmarks of aging and rejuvenating therapeutic strategies
VS Nunkoo, A Cristian, A Jurcau, RG Diaconu… - Biomedicines, 2024 - mdpi.com
The impressive achievements made in the last century in extending the lifespan have led to
a significant growth rate of elderly individuals in populations across the world and an …
a significant growth rate of elderly individuals in populations across the world and an …
Geroscience and Alzheimer's Disease Drug Development
J Cummings, AML Osse, J Kinney - The journal of prevention of …, 2023 - Springer
Age is the most important risk factor for Alzheimer's disease (AD). The acceptable age range
for participation in AD clinical trials is 50 to 90, and this 40-year span incorporates enormous …
for participation in AD clinical trials is 50 to 90, and this 40-year span incorporates enormous …
[HTML][HTML] Immune Alterations with Aging: Mechanisms and Intervention Strategies
W Yu, Y Yu, S Sun, C Lu, J Zhai, Y Lei, F Bai, R Wang… - Nutrients, 2024 - mdpi.com
Aging is the result of a complex interplay of physical, environmental, and social factors,
leading to an increased prevalence of chronic age-related diseases that burden health and …
leading to an increased prevalence of chronic age-related diseases that burden health and …
Young blood-mediated cerebromicrovascular rejuvenation through heterochronic parabiosis: enhancing blood-brain barrier integrity and capillarization in the aged …
Age-related cerebromicrovascular changes, including blood-brain barrier (BBB) disruption
and microvascular rarefaction, play a significant role in the development of vascular …
and microvascular rarefaction, play a significant role in the development of vascular …
Etanercept ameliorates chronic mild stress-induced depressive-like behavior in rats: Crosstalk between MAPK and STAT3 pathways and norepinephrine and …
Depression is a serious medical illness characterized by persistent feelings of sadness,
hopelessness, and lack of interest in daily activities. It can interfere with daily functioning and …
hopelessness, and lack of interest in daily activities. It can interfere with daily functioning and …