Ferlin proteins participate in such diverse biological events as vesicle fusion in C. elegans,
fusion of myoblast membranes to form myotubes, Ca2+-sensing during exocytosis in the hair …

We used time-resolved Förster resonance energy transfer, circular dichroism, and molecular
dynamics simulation to investigate the structural dependence of synaptotagmin 1's …

Synaptotagmin I (Syt I) is a vesicle-localized integral membrane protein that senses the
calcium ion (Ca2+) influx to trigger fast synchronous release of neurotransmitter. How the …

Eukaryotic lipids in a bilayer are dominated by weak cooperative interactions. These
interactions impart highly dynamic and pliable properties to the membrane. C2 domain …

Allostery is the key mechanism enabling a “remote” regulation of the activity of proteins and
other biological macromolecules. It forms the basis for controlling various inter-and …

This thesis applied spectroscopy and molecular dynamics simulation to study the structural
biology of actin-binding domains (ABDs) from the spectrin superfamily of proteins as well as …

The signaling response of membrane modulated proteins are influenced by their complex
lipid environments. To further understand the mechanistic role of their signaling response …

Macroscopic characteristics of a peptide or protein are dependent on microscopic
properties. One microscopic property that has an effect on the macroscopic characteristics is …

Secondary structure of protein sequences is dependent on both internal and external
interactions of amino acid residues and ligand-binding partners. Internal residue features …

The force generated by muscle cells places a high amount of stress on their plasma
membranes creating lesions which must be effectively repaired in order for the cell to …