Mesothelial cells are fundamental to the maintenance of serosal integrity and homeostasis
and play a critical role in normal serosal repair following injury. However, when normal …

The peritoneum defines a confined microenvironment, which is stable under normal
conditions, but is exposed to the damaging effect of infections, surgical injuries, and other …

Peritoneal fibrosis is a common complication of peritoneal dialysis (PD) with a complicated
pathogenesis and limited treatments. Parthenolide (PTL), a recognized nuclear factor-κB …

Trimethylamine-N-oxide (TMAO), a gut microbiota-produced metabolite, is accumulated in
chronic kidney disease (CKD) patients. It is well known to contribute to CKD-related …

Inflammation is one of the well-recognized nontraditional risk factors that contributes to the
excessive cardiovascular mortality in peritoneal dialysis (PD) patients. Serum C-reactive …

Peritoneal dialysis (PD) is a therapeutic option for the treatment of end‐stage renal disease
and is based on the use of the peritoneum as a semipermeable membrane for the exchange …

Transforming growth factor (TGF)-β/Smad signalling plays a central role in the pathogenesis
of peritoneal fibrosis related to peritoneal dialysis (PD). Parthenolide (PTL), a naturally …

Encapsulating peritoneal sclerosis (EPS) is a devastating but, fortunately, rare complication
of long-term peritoneal dialysis. The disease is associated with extensive thickening and …

Background: Chronic kidney disease (CKD) is an increasingly prevalent disease that affects
approximately 10–12% of the global population. Therefore, it is considered a public health …

Peritoneal dialysis (PD) can result in chronic inflammation and progressive peritoneal
membrane damage. Alanyl-Glutamine (Ala-Gln), a dipeptide with immunomodulatory effects …