Lyophilization and development of solid protein pharmaceuticals

W Wang - International journal of pharmaceutics, 2000 - Elsevier
Developing recombinant protein pharmaceuticals has proved to be very challenging
because of both the complexity of protein production and purification, and the limited …

Interactions of formulation excipients with proteins in solution and in the dried state

S Ohtake, Y Kita, T Arakawa - Advanced drug delivery reviews, 2011 - Elsevier
A variety of excipients are used to stabilize proteins, suppress protein aggregation, reduce
surface adsorption, or to simply provide physiological osmolality. The stabilizers encompass …

[图书][B] Food properties handbook

MS Rahman - 2009 - taylorfrancis.com
Dramatically restructured, more than double in size, the second edition of the Food
Properties Handbook has been expanded from seven to 24 chapters. In the more than ten …

The trehalose myth revisited: introduction to a symposium on stabilization of cells in the dry state

JH Crowe, LM Crowe, AE Oliver, N Tsvetkova… - Cryobiology, 2001 - Elsevier
This essay is an introduction to a series of papers arising from a symposium on stabilization
of cells in the dry state. Nearly all of these investigations have utilized the sugar trehalose as …

State diagram of foods: Its potential use in food processing and product stability

MS Rahman - Trends in Food Science & Technology, 2006 - Elsevier
State diagram is a map of the different states of a food as a function of water or solids content
and temperature. The main advantage of drawing map is in identifying different states of a …

Towards an improved understanding of glass transition and relaxations in foods: molecular mobility in the glass transition range

D Champion, M Le Meste, D Simatos - Trends in food science & technology, 2000 - Elsevier
Recent research has contributed to a better understanding of the glass–liquid transition
(GLT) and its relationship with relaxation processes in the material. This paper reviews …

Correlations between molecular mobility and chemical stability during storage of amorphous pharmaceuticals

S Yoshioka, Y Aso - Journal of pharmaceutical sciences, 2007 - Elsevier
Recent studies have demonstrated that molecular mobility is an important factor affecting the
chemical stability of amorphous pharmaceuticals, including small-molecular-weight drugs …

Food preservation by freezing

MS Rahman, JF Velez-Ruiz - Handbook of food preservation, 2007 - api.taylorfrancis.com
CONTENTS 26.1 Freezing in Biological Materials.............................................................................
..................... 636 26.2 Mode of Preserving Action …

Molecular mobility around the glass transition temperature: a mini review

G Roudaut, D Simatos, D Champion… - Innovative Food Science …, 2004 - Elsevier
This paper consists of a non-exhaustive review of molecular mobility in relation to the glass
transition, based on both synthetic polymer and food science literature. The glass transition …

Physical and functional properties of blackberry freeze-and spray-dried powders

L Franceschinis, DM Salvatori, N Sosa… - Drying …, 2014 - Taylor & Francis
The aim of the present work was to develop two products from blackberry juice by freeze and
spray drying with potential use as food colorants or healthy ingredients. A characterization of …