Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …

Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …

Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …

Highlights•Cells exposed to TLR ligands and cytokines during infection activate
PANoptosis.•RIPK1-dependent PANoptosome is formed when cell survival signaling is …

The production of various reactive oxidant species in excess of endogenous antioxidant
defense mechanisms promotes the development of a state of oxidative stress, with …

Microbial infection initiates complex interactions between the pathogen and the host.
Pathogens express several signature molecules, known as pathogen-associated molecular …

Inflammasomes are multiprotein complexes that activate caspase-1, which leads to
maturation of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 and the …

Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …

Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …