Tau-targeting therapies for Alzheimer disease: current status and future directions

EE Congdon, C Ji, AM Tetlow, Y Jiang… - Nature Reviews …, 2023 - nature.com
Alzheimer disease (AD) is the most common cause of dementia in older individuals. AD is
characterized pathologically by amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the …

[HTML][HTML] From zinc homeostasis to disease progression: Unveiling the neurodegenerative puzzle

YG Fan, TY Wu, LX Zhao, RJ Jia, H Ren, WJ Hou… - Pharmacological …, 2024 - Elsevier
Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …

Are therapies that target α-synuclein effective at halting Parkinson's disease progression? A systematic review

AT Rodger, M ALNasser, WG Carter - International Journal of Molecular …, 2023 - mdpi.com
There are currently no pharmacological treatments available that completely halt or reverse
the progression of Parkinson's Disease (PD). Hence, there is an unmet need for …

Precise photodynamic therapy by midkine nanobody-engineered nanoparticles remodels the microenvironment of pancreatic ductal adenocarcinoma and potentiates …

C Qu, H Yuan, M Tian, X Zhang, P Xia, G Shi, R Hou… - ACS …, 2024 - ACS Publications
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance against
chemotherapy and immunotherapy due to its dense desmoplastic and immunosuppressive …

Nanozyme enabled protective therapy for neurological diseases

F Cheng, S Kotha, M Fu, Q Yang, H Wang, W He… - Nano Today, 2024 - Elsevier
Nanozymes are nanomaterials that mimic enzymatic activities found in natural human
biological processes. Nanozymes can perform reactive oxidative species (ROS) scavenging …

Discovery of nanobodies: a comprehensive review of their applications and potential over the past five years

E Alexander, KW Leong - Journal of Nanobiotechnology, 2024 - Springer
Nanobodies (Nbs) are antibody fragments derived from heavy-chain-only IgG antibodies
found in the Camelidae family as well as cartilaginous fish. Their unique structural and …

NANOBODY® Molecule, a Giga Medical Tool in Nanodimensions

S Kunz, M Durandy, L Seguin, CC Feral - International Journal of …, 2023 - mdpi.com
Although antibodies remain the most widely used tool for biomedical research, antibody
technology is not flawless. Innovative alternatives, such as Nanobody® molecules, were …

Biosensors for Parkinson's Disease: Where Are We Now, and Where Do We Need to Go?

GM Maddocks, M Eisenstein, HT Soh - ACS sensors, 2024 - ACS Publications
Parkinson's Disease is the second most common neurological disease in the United States,
yet there is no cure, no pinpointed cause, and no definitive diagnostic procedure …

Molecular and cellular interactions in pathogenesis of sporadic Parkinson disease

LP Dolgacheva, VP Zinchenko… - International Journal of …, 2022 - mdpi.com
An increasing number of the population all around the world suffer from age-associated
neurodegenerative diseases including Parkinson's disease (PD). This disorder presents …

Modulating α-synuclein propagation and decomposition: implications in Parkinson's disease therapy

B Li, X Xiao, M Bi, Q Jiao, X Chen, C Yan, X Du… - Ageing Research …, 2024 - Elsevier
Abstract α-Synuclein (α-Syn) is closely related to the pathogenesis of Parkinson's disease
(PD). Under pathological conditions, the conformation of α-syn changes and different forms …