Understanding health inequalities through the lens of social epigenetics
Longstanding racial/ethnic inequalities in morbidity and mortality persist in the United States.
Although the determinants of health inequalities are complex, social and structural factors …
Although the determinants of health inequalities are complex, social and structural factors …
Integrating DNA methylation measures of biological aging into social determinants of health research
L Raffington, DW Belsky - Current Environmental Health Reports, 2022 - Springer
Abstract Purpose of Review Acceleration of biological processes of aging is hypothesized to
drive excess morbidity and mortality in socially disadvantaged populations. DNA methylation …
drive excess morbidity and mortality in socially disadvantaged populations. DNA methylation …
Associations of age, sex, race/ethnicity, and education with 13 epigenetic clocks in a nationally representative US sample: the Health and Retirement Study
Background Many DNA methylation-based indicators have been developed as summary
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
High social status males experience accelerated epigenetic aging in wild baboons
Aging, for virtually all life, is inescapable. However, within populations, biological aging rates
vary. Understanding sources of variation in this process is central to understanding the …
vary. Understanding sources of variation in this process is central to understanding the …
Testing Black-White disparities in biological aging among older adults in the United States: analysis of DNA-methylation and blood-chemistry methods
Biological aging is a proposed mechanism through which social determinants drive health
disparities. We conducted proof-of-concept testing of 8 DNA-methylation (DNAm) and blood …
disparities. We conducted proof-of-concept testing of 8 DNA-methylation (DNAm) and blood …
Education and lifestyle factors are associated with DNA methylation clocks in older African Americans
DNA methylation (DNAm) clocks are important biomarkers of cellular aging and are
associated with a variety of age-related chronic diseases and all-cause mortality. Examining …
associated with a variety of age-related chronic diseases and all-cause mortality. Examining …
Association of neighborhood deprivation with epigenetic aging using 4 clock metrics
Importance Neighborhood deprivation is associated with age-related disease, mortality, and
reduced life expectancy. However, biological pathways underlying these associations are …
reduced life expectancy. However, biological pathways underlying these associations are …
Sociodemographic and lifestyle factors and epigenetic aging in US young adults: NIMHD social epigenomics program
Importance Epigenetic clocks represent molecular evidence of disease risk and aging
processes and have been used to identify how social and lifestyle characteristics are …
processes and have been used to identify how social and lifestyle characteristics are …
“Epigenetic clocks”: Theory and applications in human biology
CP Ryan - American Journal of Human Biology, 2021 - Wiley Online Library
All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …
person. This deviation between apparent age and chronological age is often referred to as …
Longitudinal changes in epigenetic age acceleration across childhood and adolescence
Importance Individuals exposed to discrimination may exhibit greater epigenetic age
acceleration (ie, cellular indicators of premature aging) over time, but few studies have …
acceleration (ie, cellular indicators of premature aging) over time, but few studies have …