Tumors have evolved in various mechanisms to evade the immune system, hindering the
antitumor immune response and facilitating tumor progression. Immunotherapy has become …

Membranes are flexible barriers that surround the cell and its compartments. To execute vital
functions such as locomotion or receptor turnover, cells need to control the shapes of their …

Living cells display complex signal processing behaviors, many of which are mediated by
networks of proteins specialized for signal transduction. Here we focus on the question of …

An increasing number of SH3 domain–ligand interactions continue to be described that
involve the conserved peptide-binding surface of SH3, but structurally deviate substantially …

Protein–protein interactions occurring via the recognition of short peptide sequences by
modular interaction domains play a central role in the assembly of signalling protein …

Abstract Src homology 3 (SH3) domains are involved in the regulation of important cellular
pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of …

SH3 domains are protein modules that mediate protein-protein interactions in many
eukaryotic signal transduction pathways. The majority of SH3 domains studied thus far act …

Background: Metastasis is the primary cause of death in most human cancers, and
understanding the molecular mechanisms underpinning this multistep process is …

Extracellular matrix (ECM) proteins are biosynthesized in the rough endoplasmic reticulum
(rER) and transported via the Golgi apparatus to the extracellular space. The coat protein …

Introduction 3. Conventional and atypical sequence motifs 3.1. Canonical peptide motifs
recognized by the SH3 domains 3.2. Atypical SH3-binding motifs 3.3. The RxxK motif 4 …