Platinum drugs (cisplatin, oxaliplatin, and carboplatin) and arsenic trioxide are the only
commercial inorganic non-radioactive anticancer drugs approved by the US Food and Drug …

Acute promyelocytic leukemia (APL)/blood cancer is M3 type of acute myeloid leukemia
(AML) formed inside bone marrow through chromosomal translocation mutation usually …

Acute promyelocytic leukemia (APL) is characterized by arrested differentiation of
promyelocytes. Patients treated with all-trans retinoic acid (ATRA) alone experience relapse …

All-trans retinoic acid (atRA), one of the active ingredients of vitamin A, exerts canonical
activities to regulate gene expression mediated by nuclear RA receptors (RARs). AtRA could …

Retinoic acid (RA) is the active ingredient of vitamin A. It exerts its canonical activity by
binding to nuclear RA receptors (RARs) to regulate gene expression. Increasingly, RA is …

All-trans retinoic acid (RA) and interferons (IFNs) have efficacy in treating certain leukemias
and lymphomas, respectively, motivating interest in their mechanism of action to improve …

Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy with
historically high mortality rates. The treatment strategies for AML is still internationally based …

Objective Autophagy and apoptosis play key roles in cancer survival and pathogenesis and
are governed by specific genes which have a dual role in both cell death and survival …

OBJECTIVE: This study aimed to investigate the effect of all-trans retinoic acid (ATRA)
and/or arsenic trioxide (As2O3) on homeobox B8 (HOXB8) mRNA and protein expressions …

Retinoic acid (RA) is a fundamental regulator of cell cycle and cell differentiation. Using a
leukemic patient-derived in vitro model of a non-APL AML, we previously found that RA …