Chagas disease (CD), or American trypanosomiasis, causes more than 10,000 deaths per year in the Americas. Current medical therapy for CD has low efficacy in the chronic phase …
Heterocyclization of N-(1-chloro-2,2,2-trifluoroethylidene)carbamates with β-enaminoesters—a novel synthetic strategy to functionalized trifluoromethylated pyrimidines - ScienceDirect …
PA Moraes, MM Lobo, MA Marangoni… - Organic & …, 2019 - pubs.rsc.org
Reaction of 5-bromo enones with pyrazoles provided a series of unexpected N, O-aminal derivatives, through a 1, 4-conjugated addition at the β-carbon of the 5-bromo enones …
N Zanatta, CC Madruga, PC Marisco… - Journal of …, 2010 - search.ebscohost.com
Abstract < GRAPHIC> </GRAPHIC> The synthesis and chemoselective study of a novel series N-methyl-2-methylthio-tetrahydropyrimidines and or N-methyl-2 …
S Rostamizadeh, M Nojavan - Journal of Heterocyclic …, 2014 - Wiley Online Library
Some novel 4‐amino‐6‐aryl‐2‐methylthio pyrimidine‐5‐carbonitrile derivatives were synthesized through a one‐pot three‐component reaction of an aldehyde, malononitrile, and …
OO Stepaniuk, VO Matvienko, IS Kondratov… - …, 2012 - thieme-connect.com
Abstract The reactions of ethyl (4, 5-dihydrofuran-3-yl)-2-oxoacetate and ethyl 2-(3, 4- dihydro-2H-pyran-6-yl)-2-oxoacetate, as 1, 3-bielectrophiles, with N-unsubstituted 5 …
A simple and highly chemoselective method for the synthesis of a large series of novel 6‐ alkoxy‐1‐alkyl (aryl)‐3‐trifluoroacetyl‐1, 4, 5, 6‐tetrahydropyridines and 1‐alkyl (aryl)‐6 …
A Bhattacharyya - Current Organic Chemistry, 2019 - ingentaconnect.com
Partially reduced heterocyclic compounds such as 1, 4, 5, 6-tetrahydropyrimidines are often found to possess interesting pharmacological properties. Yet, the synthetic routes towards …