Five-membered cyclic carbonates: Versatility for applications in organic synthesis, pharmaceutical, and materials sciences
P Rollin, LK Soares, AM Barcellos, DR Araujo… - Applied Sciences, 2021 - mdpi.com
This review presents the recent advances involving several applications of five-membered
cyclic carbonates and derivatives. With more than 150 references, it covers the period from …
cyclic carbonates and derivatives. With more than 150 references, it covers the period from …
Recent advances in DNA gyrase-targeted antimicrobial agents
Antimicrobial resistance is one of the greatest challenges facing the world today. In the
United States alone, it is responsible for the death of more than 20,000 people each year …
United States alone, it is responsible for the death of more than 20,000 people each year …
Discovery of benzothiazole scaffold-based DNA gyrase B inhibitors
M Gjorgjieva, T Tomasic, M Barancokova… - Journal of medicinal …, 2016 - ACS Publications
Bacterial DNA gyrase and topoisomerase IV control the topological state of DNA during
replication and are validated targets for antibacterial drug discovery. Starting from our …
replication and are validated targets for antibacterial drug discovery. Starting from our …
N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target …
Due to the occurrence of antibiotic resistance, bacterial infectious diseases have become a
serious threat to public health. To overcome antibiotic resistance, novel antibiotics are …
serious threat to public health. To overcome antibiotic resistance, novel antibiotics are …
Discovery of substituted oxadiazoles as a novel scaffold for DNA gyrase inhibitors
DNA gyrase and topoisomerase IV are type IIa topoisomerases that are essential bacterial
enzymes required to oversee the topological state of DNA during transcription and …
enzymes required to oversee the topological state of DNA during transcription and …
Exploring the chemical space of benzothiazole-based DNA gyrase B inhibitors
Z Skok, M Barančoková, O Benek… - ACS medicinal …, 2020 - ACS Publications
We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase
and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor …
and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor …
Piperazine-azole-fluoroquinolone hybrids: Conventional and microwave irradiated synthesis, biological activity screening and molecular docking studies
Abstract A series of new 1, 2, 4-triazole and 1, 3, 4-oxadiazole derivatives was obtained via
several steps sequential reactions of phenyl piperazine. Then, these compounds were …
several steps sequential reactions of phenyl piperazine. Then, these compounds were …
Synthesis and Evaluation of N‐Phenylpyrrolamides as DNA Gyrase B Inhibitors
ATP‐competitive inhibitors of DNA gyrase and topoisomerase IV are among the most
interesting classes of antibacterial drugs that are unrepresented in the antibacterial pipeline …
interesting classes of antibacterial drugs that are unrepresented in the antibacterial pipeline …
Recent progress in the discovery and development of DNA gyrase B inhibitors
New antibacterials that modulate less explored targets are needed to fight the emerging
bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search …
bacterial resistance. DNA gyrase and topoisomerase IV are attractive targets in this search …
Benzothiazole-based compounds in antibacterial drug discovery
Numerous compounds with a benzothiazole scaffold that have been described in the
literature show promising activities against several Gram-positive and Gramnegative …
literature show promising activities against several Gram-positive and Gramnegative …