Newly diagnosed glioblastoma is now commonly treated with surgery, if feasible, or biopsy,
followed by radiation plus concomitant and adjuvant temozolomide. The treatment of …

Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of
brain tumors remains a challenge. This is particularly true for the most frequent and fatal …

Purpose To determine the efficacy and toxicity of re-irradiation for patients with recurrent
GBM. Materials and methods We searched various biomedical databases from 1998 to …

Background Glioblastoma (GBM) is a highly malignant brain tumour that almost inevitably
progresses or recurs after first line standard of care. There is no consensus regarding the …

Radiation therapy is an integral part of the standard treatment paradigm for malignant
gliomas, with proven efficacy in randomized control trials. Radiation treatment is not without …

Studies looking at the benefit of surgery at first relapse (second surgery) for recurrent
glioblastoma were confounded by including patients with varying grades of glioma …

The optimal management of recurrent glioblastoma (GBM) has yet to be determined. We aim
to assess the benefits of re-operation and salvage therapies (chemotherapy and/or re …

Question Can re-irradiation (by using conventional radiotherapy, fractionated radiosurgery,
or single fraction radiosurgery) be used in patients with progressive glioblastoma multiforme …

Glioblastoma multiforme is a devastating disease of the central nervous system and, at
present, no effective therapeutic interventions have been identified. Celastrol, a natural …

Question Which imaging techniques most accurately differentiate true tumor progression
from pseudo-progression or treatment related changes in patients with previously diagnosed …