Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

Background & Aims Activation of Wnt signaling to β-catenin contributes to the development
of colorectal cancer (CRC). Expression of tribbles pseudo-kinase 3 (TRIB3) is increased in …

Cancer stem cells (CSCs), also known as tumor-initiating cells, are a subpopulation of tumor
cells that exhibit properties similar to those of normal stem cells. Oxygen is an important …

The aging central nervous system (CNS) of mammals displays progressive limited
regenerative abilities. Recovery after loss of neurons is extremely restricted in the aged …

Abstract The African turquoise killifish (Nothobranchius furzeri) combines a short lifespan
with spontaneous age‐associated loss of neuro‐regenerative capacity, an intriguing trait …

Cell polarity is essential for many functions of cells and tissues including the initial
establishment and subsequent maintenance of epithelial tissues, asymmetric cell division …

Oligodendrocyte progenitor cells (OPC) undergo asymmetric cell division (ACD) to generate
one OPC and one differentiating oligodendrocyte (OL) progeny. Loss of pro-mitotic …

To investigate the putative stem cell/tumor stem cell (SC/TSC) niche contribution to
hyperplasic/adenomatous pituitary lesions, we analyzed variation in the pituitary stem cell …

Maternal obesity or exposure to a high-fat diet (HFD) has an irreversible impact on the
structural and functional development of offspring brains. This study aimed to investigate …