Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-
functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor …

Digital PCR enabled high-sensitivity and quantitative measurements of rare biological
variants. A new digital droplet-enabled PCR technology was introduced in this paper, which …

Fibroblasts derived from embryos homozygous for a disruption of the retinoblastoma gene
(Rb) exhibit a shorter G1 than their wild-type counterparts, apparently due to highly elevated …

Although the retinoblastoma-susceptibility gene RB1 is inactivated in a wide range of human
tumours, in colorectal cancer, the retinoblastoma protein (Rb) function is often preserved …

In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivated by mutation in
the RB gene or functionally inhibited by abnormal activation of cyclin-dependent kinase …

Abstract The RB1/E2F1 signaling pathway is frequently deregulated in colorectal cancer and
has been suggested to intersect with Wnt/β-catenin and PI3K/Akt pathways, but molecular …

A reflection of the explosion of research and development in this field, this book explores
applications of omics in bioinformatics, cancer research and therapy, diabetes research …

p16INK4 and RB1 are two potent cell cycle regulators to control the G1/S transition by
interacting with CDK4/6, E2F, and D‐type cyclins, respectively. Depending on the tumour …

We analysed the frequency of p53 mRNA overexpression in a series of 109 primary
colorectal carcinomas and its association with p53 gene mutation, which has been …

Purpose: Adequate preoperative staging of large sessile rectal tumors requires identifying
adenomas that already contain an invasive focus, specifically those that are growing in or …