Recent developments in the reduction of aromatic and aliphatic nitro compounds to amines

M Orlandi, D Brenna, R Harms, S Jost… - … Process Research & …, 2016 - ACS Publications
The reduction of the nitro group represents a powerful and widely used transformation that
allows to introducing an amino group in the molecule. New synthetic strategies for complex …

Emerging technologies supporting chemical process R&D and their increasing impact on productivity in the pharmaceutical industry

AE Rubin, S Tummala, DA Both, C Wang… - Chemical …, 2006 - ACS Publications
Over the past 30 years process R&D functions within the pharmaceutical industry have
undergone a remarkable transformation. At one time the bulk of investment of time and …

Chemoselective hydrogenation of nitroaromatics at the nanoscale iron (III)–OH–platinum interface

Y Wang, R Qin, Y Wang, J Ren, W Zhou… - Angewandte Chemie …, 2020 - Wiley Online Library
Catalytic hydrogenation of nitroaromatics is an environment‐benign strategy to produce
industrially important aniline intermediates. Herein, we report that Fe (OH) x deposition on Pt …

Chemoselective hydrogenation of nitroaromatics by supported gold catalysts: mechanistic reasons of size-and support-dependent activity and selectivity

K Shimizu, Y Miyamoto, T Kawasaki… - The Journal of …, 2009 - ACS Publications
Supported Au nanoparticles (NPs) prepared by colloid deposition method were well
characterized, and their catalytic performance was tested for chemoselective reduction of a …

Fixed bed continuous hydrogenations in trickle flow mode: a pharmaceutical industry perspective

E Masson, EM Maciejewski… - … Process Research & …, 2022 - ACS Publications
Since the 1930s, fixed bed reactors (FBR) have been operated for continuous
hydrogenation reactions in the petrochemical/fine chemical industries, with publications …

Two-Chamber-Enabled Hydrogenation Reactions Using Al-H2O/NaOH: Access to Pharmaceuticals

A Iqubal, P Halder, P Das - The Journal of Organic Chemistry, 2023 - ACS Publications
In this study, an efficient method for hydrogenation reactions has been reported in a short
reaction time using a two-chamber reactor. This process involves the ex situ generation of …

4, 4′-Bipyridyl-catalyzed reduction of nitroarenes by bis (neopentylglycolato) diboron

H Hosoya, LC Misal Castro, I Sultan, Y Nakajima… - Organic …, 2019 - ACS Publications
4, 4′-Bipyridyl worked as an organocatalyst for the reduction of nitroarenes by bis
(neopentylglycolato) diboron (B2nep2), followed by hydrolysis to give the corresponding …

Rapid, efficient and selective reduction of aromatic nitro compounds with sodium borohydride and Raney nickel

I Pogorelić, M Filipan-Litvić, S Merkaš, G Ljubić… - Journal of molecular …, 2007 - Elsevier
A new efficient, mild and practical method for reduction of aromatic nitro compounds
employing NaBH4/Raney nickel system is reported. The method is simple, inexpensive …

Recent progress in the synthesis of N-substituted arylamines by reductive cross-coupling of nitroarenes

JH Qin, Y Wang, JY Ouyang, M Liu… - Organic Chemistry …, 2024 - pubs.rsc.org
Highly functionalized N-substituted arylamines are the core structural motifs of numerous
biologically active molecules, agrochemicals, and functional materials. Classically, using …

Highlights of the recent patent literature─ focus on biocatalysis innovation

DL Hughes - Organic Process Research & Development, 2022 - ACS Publications
This review surveys recent advances in biocatalysis, with a primary focus on contributions
from the patent literature since 2018, including reductive aminations, nitro reductions …