Differential gene expression gives rise to the many cell types of complex organisms.
Enhancers regulate transcription by binding transcription factors (TFs), which in turn recruit …

Chromatin immunoprecipitation experiments followed by sequencing (ChIP–seq) detect
protein–DNA binding events and chemical modifications of histone proteins. Challenges in …

Genome editing is a powerful new tool for making precise alterations to an organism's
genetic material. Recent scientific advances have made genome editing more efficient …

Abstract Model-based analysis of ChIP-seq (MACS) is a computational algorithm that
identifies genome-wide locations of transcription/chromatin factor binding or histone …

Cis-regulatory sequences, such as enhancers and promoters, control development and
physiology by regulating gene expression. Mutations that affect the function of these …

The mapping of expression quantitative trait loci (eQTLs) has emerged as an important tool
for linking genetic variation to changes in gene regulation,,,,. However, it remains difficult to …

Background DNA methylation is an essential epigenetic mechanism involved in gene
regulation and disease, but little is known about the mechanisms underlying inter-individual …

Genome and exome sequencing yield extensive catalogues of human genetic variation.
However, pinpointing the few phenotypically causal variants among the many variants …

Here we review recent advances in understanding the regulation of mRNA synthesis in
Saccharomyces cerevisiae. Many fundamental gene regulatory mechanisms have been …

The majority of disease-associated variants lie outside protein-coding regions, suggesting a
link between variation in regulatory regions and disease predisposition. We studied …