Steroids are important biodynamic agents. Their affinities for various nuclear receptors have
been an interesting feature to utilize them for drug development particularly for receptor …

Dehydronandrolone acetate (3) is a crucial precursor for the synthesis of C7-functionalized
steroidal drugs. However, the current production method involves a laborious and …

During recent years intensive research has been focused on the synthesis of structurally
modified steroid hormones in order to obtain compounds with beneficial biological activity …

Background For many years, various drugs have been used for the treatment of infectious
diseases but some bacterial microorganisms have induced resistance to several drugs. In a …

In this work, new steroidal aromatase inhibitors (AIs) were designed, synthesized, and
tested. In one approach, C-ring substituted steroids namely those functionalized at C-11 …

Steroid and its derivatives have been proved to have important and diverse biological
functions, which present the wide spectrum of biological activities such as antitumor …

C-6α and C-7α androstanes were studied to disclose which position among them is more
convenient to functionalize to reach superior aromatase inhibition. In the first series, the …

Intermolecular Cu (I)-catalyzed azide-alkyne cycloadditions of 15β-azido-17β-hydroxy-5α-
androstan-3β-yl acetate with different terminal alkynes under optimized reaction conditions …

Sixteen platinum (II) complexes of estrone and estradiol were synthesized in this work to
evaluate their cytotoxic activity against several cancer cell lines including estrogen …

Fourteen novel steroidal C-17 pyrazolinyl derivatives 9a–g and 10a–g were synthesized
from commercially available progesterone and tested for their cytotoxic activity against brine …