Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …

Many transformed lymphoma cells show immune-phenotypes resembling the corresponding
normal lymphocytes; thus, they provide a guide for proper diagnosis and present promising …

The SRY-related HMG-box family of transcription factors member SOX2 regulates stemness
and pluripotency in embryonic stem cells and plays important roles during early …

Background There is evidence that the extent of the G2/M arrest following irradiation is
correlated with tumour cell survival and hence therapeutic success. We studied the …

Recently, SOX2 has been identified as a potential lineage-specific oncogene in lung
squamous cell carcinomas. Since head and neck squamous cell carcinomas (HNSCC) are …

Background Radiation resistance presents a challenge to the effective treatment of cancer. If
therapeutic compounds were capable of resensitizing resistant tumours then a concurrent …

Background Although lentiviral transduction methods are widely used, their broader
application is dependent upon the optimization of lentiviral transduction efficiency for a …

MALT1 is the only known paracaspase and is a critical mediator of B-and T-cell receptor
signalling. The function of the MALT1 gene is subverted by oncogenic chimeric fusions …

Background: MiR-221/-222 are frequently overexpressed in breast cancer and are
associated with increased malignancy. The specific modification of microRNAs (miRNAs) …

We recently reported that miR-146a is differentially expressed in ALK+ and ALK− anaplastic
large cell lymphoma (ALCL). In this study, the downstream targets of miR-146a in ALK+ …