Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …

Atrial fibrillation (AF) is the most common supraventricular arrhythmia that, for unknown
reasons, is linked to intense endurance exercise. Our studies reveal that 6 weeks of …

Aims The overloaded heart remodels by cardiomyocyte hypertrophy and interstitial fibrosis,
which contributes to the development of heart failure. Signalling via the TGFβ-pathway is …

Objective. We evaluated the influence of exercise on functional capacity, cardiac
remodeling, and skeletal muscle oxidative stress, MAPK, and NF‐κB pathway in rats with …

Persistently unrepaired DNA damage has been identified as a causative factor for vascular
ageing. We have previously shown that a defect in the function or expression of the DNA …

Rationale: Mechanisms underlying diastolic dysfunction need to be better understood.
Objective: To study the role of titin in diastolic dysfunction using a mouse model of …

The paralogous genes Nppa and Nppb are organized in an evolutionarily conserved cluster
and provide a valuable model for studying co-regulation and regulatory landscape …

Background Atrial fibrillation (AF) is often preceded by underlying cardiac diseases causing
ventricular pressure overload. Objective It was our aim to investigate the progression of atrial …

Fibrosis is a characteristic of many cardiac diseases for which no effective treatment exists.
We have developed an ex vivo flow system, which allows induction of cardiac fibrosis in …