Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …

Although melanoma is notorious for its high degree of heterogeneity and plasticity,, the
origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear …

The neural crest is induced at the edge between the neural plate and the nonneural
ectoderm, in an area called the neural (plate) border, during gastrulation and neurulation. In …

The ability of the pluripotent epiblast to contribute progeny to all three germ layers is thought
to be lost after gastrulation. The later-forming neural crest (NC) rises from ectoderm and it …

In the neural primordium of vertebrate embryos, the neural crest (NC) displays a unique
character: the capacity of its component cells to leave the neural primordium, migrate along …

Forebrain precursor cells are dynamic during early brain development, yet the underlying
molecular changes remain elusive. We observed major differences in transcriptional …

The molecular mechanisms that coordinate patterning of the embryonic ectoderm into
spatially distinct lineages to form the nervous system, epidermis, and neural crest-derived …

The neural crest is an embryonic population of multipotent stem cells that form numerous
defining features of vertebrates. Due to lack of reliable techniques to perform transcriptional …

Guanine-rich DNA strands can fold into non-canonical four-stranded secondary structures
named G-quadruplexes (G4). Experimental evidences suggest that G4-DNA surrounding …

The neural crest is a migratory stem cell population that contributes to various tissues and
organs during vertebrate embryonic development. These cells possess remarkable …