The circadian (∼ 24h) clock is based on a negative-feedback loop centered around the
PERIOD protein (PER), translated in the cytoplasm and then enters the nucleus to repress its …

The circadian clock is based on a transcriptional feedback loop with an essential time delay
before feedback inhibition. Previous work has shown that PERIOD (PER) proteins generate …

Modeling biochemical reactions by means of differential equations often results in systems
with a large number of variables and parameters. As this might complicate the interpretation …

Thoughtful use of simplifying assumptions is crucial to make systems biology models
tractable while still representative of the underlying biology. A useful simplification can …

Regular transitions between interphase and mitosis during the cell cycle are driven by
changes in the activity of the enzymatic protein complex cyclin B with cyclin-dependent …

Social insects owe their widespread success to their ability to efficiently coordinate
behaviour to carry out complex tasks. Several leaf-cutter ant species employ an advanced …

Many biochemical oscillators are driven by the periodic rise and fall of protein
concentrations or activities. A negative feedback loop underlies such oscillations. The …

We review a series of key travelling front problems in reaction–diffusion systems with a time-
delayed feedback, appearing in ecology, nonlinear optics and neurobiology. For each …

In this study we show that concept of backward bifurcation, borrowed from epidemics, can be
fruitfully exploited to shed light on the mechanism underlying the occurrence of hysteresis in …

In an oscillatory medium, a region which oscillates faster than its surroundings can act as a
source of outgoing waves. Such pacemaker-generated waves can synchronize the whole …