[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly

S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …

Cellular stress leads to the formation of membraneless stress assemblies in eukaryotic cells

W van Leeuwen, C Rabouille - Traffic, 2019 - Wiley Online Library
In cells at steady state, two forms of cell compartmentalization coexist: membrane‐bound
organelles and phase‐separated membraneless organelles that are present in both the …

Multivalent proteins rapidly and reversibly phase-separate upon osmotic cell volume change

AP Jalihal, S Pitchiaya, L Xiao, P Bawa, X Jiang, K Bedi… - Molecular cell, 2020 - cell.com
Processing bodies (PBs) and stress granules (SGs) are prominent examples of subcellular,
membraneless compartments that are observed under physiological and stress conditions …

The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway

M Malecki, SC Viegas, T Carneiro, P Golik… - The EMBO …, 2013 - embopress.org
The final step of cytoplasmic mRNA degradation proceeds in either a 5′‐3′ direction
catalysed by Xrn1 or in a 3′‐5′ direction catalysed by the exosome. Dis3/Rrp44, an …

Chaperone-facilitated aggregation of thermo-sensitive proteins shields them from degradation during heat stress

M Cabrera, S Boronat, L Marte, M Vega, P Pérez… - Cell Reports, 2020 - cell.com
Cells have developed protein quality-control strategies to manage the accumulation of
misfolded substrates during heat stress. Using a soluble reporter of misfolding in fission …

The Crz1/Sp1 Transcription Factor of Cryptococcus neoformans Is Activated by Calcineurin and Regulates Cell Wall Integrity

S Lev, D Desmarini, M Chayakulkeeree, TC Sorrell… - PloS one, 2012 - journals.plos.org
Cryptococcus neoformans survives host temperature and regulates cell wall integrity via a
calcium-dependent phosphatase, calcineurin. However, downstream effectors of C …

Yeast stress granules at a glance

T Grousl, J Vojtova, J Hasek, T Vomastek - Yeast, 2022 - Wiley Online Library
The formation of stress granules (SGs), membrane‐less organelles that are composed of
mainly messenger ribonucleoprotein assemblies, is the result of a conserved evolutionary …

Lsm7 phase-separated condensates trigger stress granule formation

M Lindström, L Chen, S Jiang, D Zhang, Y Gao… - Nature …, 2022 - nature.com
Stress granules (SGs) are non-membranous organelles facilitating stress responses and
linking the pathology of age-related diseases. In a genome-wide imaging-based phenomic …

Differential Localization of the Two T. brucei Poly(A) Binding Proteins to the Nucleus and RNP Granules Suggests Binding to Distinct mRNA Pools

S Kramer, B Bannerman-Chukualim, L Ellis… - PLoS …, 2013 - journals.plos.org
The number of paralogs of proteins involved in translation initiation is larger in
trypanosomes than in yeasts or many metazoan and includes two poly (A) binding proteins …

3D-printed microfluidic microdissector for high-throughput studies of cellular aging

EC Spivey, B Xhemalce, JB Shear… - Analytical …, 2014 - ACS Publications
Due to their short lifespan, rapid division, and ease of genetic manipulation, yeasts are
popular model organisms for studying aging in actively dividing cells. To study replicative …