Clostridioides difficile toxins: mechanisms of action and antitoxin therapeutics

SL Kordus, AK Thomas, DB Lacy - Nature Reviews Microbiology, 2022 - nature.com
Clostridioides difficile is a Gram-positive anaerobe that can cause a spectrum of disorders
that range in severity from mild diarrhoea to fulminant colitis and/or death. The bacterium …

Cellulolytic bacteria in the large intestine of mammals

A Froidurot, V Julliand - Gut Microbes, 2022 - Taylor & Francis
The utilization of dietary cellulose by resident bacteria in the large intestine of mammals,
both herbivores and omnivores (including humans), has been a subject of interest since the …

Enterococci enhance Clostridioides difficile pathogenesis

AB Smith, ML Jenior, O Keenan, JL Hart, J Specker… - Nature, 2022 - nature.com
Enteric pathogens are exposed to a dynamic polymicrobial environment in the
gastrointestinal tract. This microbial community has been shown to be important during …

Effect of Clostridium butyricum on Gastrointestinal Infections

T Ariyoshi, M Hagihara, M Takahashi, H Mikamo - Biomedicines, 2022 - mdpi.com
Clostridium butyricum is a human commensal bacterium with beneficial effects including
butyrate production, spore formation, increasing levels of beneficial bacteria, and inhibition …

Intestinal stem cell-on-chip to study human host-microbiota interaction

F Siwczak, E Loffet, M Kaminska, H Koceva… - Frontiers in …, 2021 - frontiersin.org
The gut is a tubular organ responsible for nutrient absorption and harbors our intestinal
microbiome. This organ is composed of a multitude of specialized cell types arranged in …

The gut bacterial community potentiates Clostridioides difficile infection severity

NA Lesniak, AM Schubert, KJ Flynn, JL Leslie, H Sinani… - MBio, 2022 - Am Soc Microbiol
The severity of Clostridioides difficile infections (CDI) has increased over the last few
decades. Patient age, white blood cell count, and creatinine levels as well as C. difficile …

Wolf in Sheep's Clothing: Clostridioides difficile Biofilm as a Reservoir for Recurrent Infections

J Meza-Torres, E Auria, B Dupuy, YDN Tremblay - Microorganisms, 2021 - mdpi.com
The microbiota inhabiting the intestinal tract provide several critical functions to its host.
Microorganisms found at the mucosal layer form organized three-dimensional structures …

“Bacterial Consortium”: A Potential Evolution of Fecal Microbiota Transplantation for the Treatment of Clostridioides difficile Infection

G Quaranta, G Ianiro, F De Maio… - BioMed Research …, 2022 - Wiley Online Library
Fecal microbiota transplantation (FMT) consists of infusion of feces from a donor to a
recipient patient in order to restore the resident microbial population. FMT has shown to be a …

Evolutionary modeling suggests that addictions may be driven by competition-induced microbiome dysbiosis

O Lewin-Epstein, Y Jaques, MW Feldman… - Communications …, 2023 - nature.com
Recent studies revealed mechanisms by which the microbiome affects its host's brain,
behavior and wellbeing, and that dysbiosis–persistent microbiome-imbalance–is associated …

Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile

YDN Tremblay, BAR Durand, A Hamiot… - The ISME …, 2021 - academic.oup.com
Clostridioides difficile infections are associated with gut microbiome dysbiosis and are the
leading cause of hospital-acquired diarrhoea. The infectious process is strongly influenced …