Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise
NS Carter, BD Stamper, F Elbarbry, V Nguyen, S Lopez… - Microorganisms, 2021 - mdpi.com
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans worldwide. Because a vaccine is not available and the currently small number of …
humans worldwide. Because a vaccine is not available and the currently small number of …
[HTML][HTML] Immunotherapeutic Strategies as Potential Treatment Options for Cutaneous Leishmaniasis
Cutaneous leishmaniasis (CL), caused by protozoan parasites of the Leishmania genus, is
prevalent in tropical and subtropical regions, with important morbidity, particularly in low-to …
prevalent in tropical and subtropical regions, with important morbidity, particularly in low-to …
Arginase 1 expression by macrophages promotes Cryptococcus neoformans proliferation and invasion into brain microvascular endothelial cells
A Hansakon, C Ngamphiw, S Tongsima… - The Journal of …, 2023 - journals.aai.org
Cryptococcal meningoencephalitis caused by Cryptococcus neoformans infection is the
most common cause of death in HIV/AIDS patients. Macrophages are pivotal for the …
most common cause of death in HIV/AIDS patients. Macrophages are pivotal for the …
Arginase inhibitor reduces fungal dissemination in murine pulmonary cryptococcosis by promoting anti-cryptococcal immunity
A Hansakon, P Angkasekwinai - International Immunopharmacology, 2024 - Elsevier
Elevation of arginase enzyme activity in the lung contributes to the pathogenesis of various
chronic inflammatory diseases and infections. Inhibition of arginase expression and activity …
chronic inflammatory diseases and infections. Inhibition of arginase expression and activity …
Anti-leishmanial therapy: Caught between drugs and immune targets
H Mahor, A Mukherjee, A Sarkar, B Saha - Experimental Parasitology, 2023 - Elsevier
Leishmaniasis is an enigmatic disease that has very restricted options for chemotherapy and
none for prophylaxis. As a result, deriving therapeutic principles for curing the disease has …
none for prophylaxis. As a result, deriving therapeutic principles for curing the disease has …
Therapeutic Modulation of Arginase with nor-NOHA Alters Immune Responses in Experimental Mouse Models of Pulmonary Tuberculosis including in the Setting of …
S Chauhan, RJ Nusbaum, MB Huante… - Tropical Medicine and …, 2024 - mdpi.com
L-arginine metabolism is strongly linked with immunity to mycobacteria, primarily through the
antimicrobial activity of nitric oxide (NO). The potential to modulate tuberculosis (TB) …
antimicrobial activity of nitric oxide (NO). The potential to modulate tuberculosis (TB) …
Inhibiting Human and Leishmania Arginases Using Cannabis sativa as a Potential Therapy for Cutaneous Leishmaniasis: A Molecular Docking Study
A Assouab, H El Filaly, K Akarid - Tropical Medicine and Infectious …, 2022 - mdpi.com
Cutaneous leishmaniasis (CL), a vector-borne parasitic disease caused by the Leishmania
protozoan, is a serious public health problem in Morocco. The treatment of this disease is …
protozoan, is a serious public health problem in Morocco. The treatment of this disease is …