Advanced biomaterials in cell preservation: Hypothermic preservation and cryopreservation

Y Ma, L Gao, Y Tian, P Chen, J Yang, L Zhang - Acta Biomaterialia, 2021 - Elsevier
Cell-based medicine has made great advances in clinical diagnosis and therapy for various
refractory diseases, inducing a growing demand for cell preservation as support technology …

Targeting dendritic cell function during systemic autoimmunity to restore tolerance

JP Mackern-Oberti, F Vega, C Llanos… - International journal of …, 2014 - mdpi.com
Systemic autoimmune diseases can damage nearly every tissue or cell type of the body.
Although a great deal of progress has been made in understanding the pathogenesis of …

[HTML][HTML] Cryopreservation preserves cell-type composition and gene expression profiles in bone marrow aspirates from multiple myeloma patients

D Chen, MI Abu Zaid, JL Reiter, M Czader… - Frontiers in …, 2021 - frontiersin.org
Single-cell RNA sequencing reveals gene expression differences between individual cells
and also identifies different cell populations that are present in the bulk starting material. To …

[HTML][HTML] Feasibility of using monocyte-derived dendritic cells obtained from cryopreserved cells for DC-based vaccines

L Usero, L Miralles, I Esteban… - Journal of …, 2021 - Elsevier
The study of the effect of cryopreservation on the functionality of monocyte-derived dendritic
cells (MDDCs) and dendritic cells (DCs) is essential for their use in different clinical …

Altered monocyte phenotype in HIV-1 infection tends to normalize with integrase-inhibitor-based antiretroviral therapy

MR McCausland, SM Juchnowski, DA Zidar… - PLoS …, 2015 - journals.plos.org
Background Monocytes are increasingly implicated in the inflammatory consequences of
HIV-1 disease, yet their phenotype following antiretroviral therapy (ART) initiation is …

Freezing of dendritic cells with trehalose as an additive in the conventional freezing medium results in improved recovery after cryopreservation

P Shinde, N Khan, S Melinkeri, V Kale, L Limaye - Transfusion, 2019 - Wiley Online Library
BACKGROUND Dendritic cell (DC) vaccination involves administration of multiple doses.
Cryopreservation of tumor antigen–pulsed DCs can provide a ready to use vaccine source …

Improvement of bone marrow mononuclear cells cryopreservation methods to increase the efficiency of dendritic cell production

H Kysielova, K Yampolska, T Dubrava, O Lutsenko… - Cryobiology, 2022 - Elsevier
Cryopreservation is now considered an integral part of the biotechnological process,
exploiting different types of cells and tissues in clinical practice. Among them, dendritic cells …

Mature dendritic cell derived from cryopreserved immature dendritic cell shows impaired homing ability and reduced anti-viral therapeutic effects

Q Zhou, Y Zhang, M Zhao, X Wang, C Ma, X Jiang… - Scientific reports, 2016 - nature.com
Cryopreservation is critical in reducing redundant operations and also in quality control in
dendritic cell (DC) therapy. Full maturation and efficient homing of DCs to T cell-region …

Immunomodulatory Effects of 1,25‐Dihydroxyvitamin D3 on Dendritic Cells Promote Induction of T Cell Hyporesponsiveness to Myelin‐Derived Antigens

WP Lee, B Willekens, P Cras… - Journal of …, 2016 - Wiley Online Library
While emerging evidence indicates that dendritic cells (DC) play a central role in the
pathogenesis of multiple sclerosis (MS), their modulation with immunoregulatory agents …

Dendritic cell-based immunotherapy in advanced sarcoma and neuroblastoma pediatric patients: anti-cancer treatment preceding monocyte harvest impairs the …

E Hlavackova, K Pilatova, D Cerna… - Frontiers in …, 2019 - frontiersin.org
Despite efforts to develop novel treatment strategies, refractory and relapsing sarcoma, and
high-risk neuroblastoma continue to have poor prognoses and limited overall survival …