Advances in computational modelling for personalised medicine after myocardial infarction
Myocardial infarction (MI) is a leading cause of premature morbidity and mortality worldwide.
Determining which patients will experience heart failure and sudden cardiac death after an …
Determining which patients will experience heart failure and sudden cardiac death after an …
Computational modeling of cardiac fibroblasts and fibrosis
Altered fibroblast behavior can lead to pathologic changes in the heart such as arrhythmia,
diastolic dysfunction, and systolic dysfunction. Computational models are increasingly used …
diastolic dysfunction, and systolic dysfunction. Computational models are increasingly used …
Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments
Ventricular wall stress is believed to be responsible for many physical mechanisms taking
place in the human heart, including ventricular remodeling, which is frequently associated …
place in the human heart, including ventricular remodeling, which is frequently associated …
MRI evaluation of injectable hyaluronic acid-based hydrogel therapy to limit ventricular remodeling after myocardial infarction
SM Dorsey, JR McGarvey, H Wang, A Nikou, L Arama… - Biomaterials, 2015 - Elsevier
Injectable biomaterials are an attractive therapy to attenuate left ventricular (LV) remodeling
after myocardial infarction (MI). Although studies have shown that injectable hydrogels …
after myocardial infarction (MI). Although studies have shown that injectable hydrogels …
Construction and validation of subject-specific biventricular finite-element models of healthy and failing swine hearts from high-resolution DT-MRI
Predictive computational modeling has revolutionized classical engineering disciplines and
is in the process of transforming cardiovascular research. This is particularly relevant for …
is in the process of transforming cardiovascular research. This is particularly relevant for …
High-speed mechano-active multielectrode array for investigating rapid stretch effects on cardiac tissue
Systematic investigations of the effects of mechano-electric coupling (MEC) on cellular
cardiac electrophysiology lack experimental systems suitable to subject tissues to in-vivo …
cardiac electrophysiology lack experimental systems suitable to subject tissues to in-vivo …
Estimating passive mechanical properties in a myocardial infarction using MRI and finite element simulations
D Mojsejenko, JR McGarvey, SM Dorsey… - … and modeling in …, 2015 - Springer
Myocardial infarction (MI) triggers a series of maladaptive events that lead to structural and
functional changes in the left ventricle. It is crucial to better understand the progression of …
functional changes in the left ventricle. It is crucial to better understand the progression of …
I-Wire Heart-on-a-Chip II: Biomechanical analysis of contractile, three-dimensional cardiomyocyte tissue constructs
This companion study presents the biomechanical analysis of the “I-Wire” platform using a
modified Hill model of muscle mechanics that allows for further characterization of construct …
modified Hill model of muscle mechanics that allows for further characterization of construct …
Systems and methods for improving cardiac function
MD Alexander, ML Pease, BL Templin… - US Patent …, 2017 - Google Patents
(57) ABSTRACT A system for improving cardiac function is provided. A foldable and
expandable frame having at least one anchoring formation is attached to an elongate …
expandable frame having at least one anchoring formation is attached to an elongate …
In vivo estimation of passive biomechanical properties of human myocardium
Identification of in vivo passive biomechanical properties of healthy human myocardium from
regular clinical data is essential for subject-specific modelling of left ventricle (LV). In this …
regular clinical data is essential for subject-specific modelling of left ventricle (LV). In this …