Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
Single-cell immunology of SARS-CoV-2 infection
Gaining a better understanding of the immune cell subsets and molecular factors associated
with protective or pathological immunity against severe acute respiratory syndrome …
with protective or pathological immunity against severe acute respiratory syndrome …
[HTML][HTML] Multiple early factors anticipate post-acute COVID-19 sequelae
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However,
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
[HTML][HTML] Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
J Liu, J Wang, J Xu, H Xia, Y Wang, C Zhang, W Chen… - Cell Discovery, 2021 - nature.com
Large-scale COVID-19 vaccinations are currently underway in many countries in response
to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies …
to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies …
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
The immunological features that distinguish COVID-19-associated acute respiratory distress
syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report …
syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report …
Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth
The dynamics of immunity to infection in infants remain obscure. Here, we used a multi-
omics approach to perform a longitudinal analysis of immunity to severe acute respiratory …
omics approach to perform a longitudinal analysis of immunity to severe acute respiratory …
Single-cell RNA-seq methods to interrogate virus-host interactions
The twenty-first century has seen the emergence of many epidemic and pandemic viruses,
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
with the most recent being the SARS-CoV-2-driven COVID-19 pandemic. As obligate …
Collapsing focal segmental glomerulosclerosis in viral infections
Collapsing glomerulopathy represents a special variant of the proteinuric kidney disease
focal segmental glomerulosclerosis (FSGS). Histologically, the collapsing form of FSGS …
focal segmental glomerulosclerosis (FSGS). Histologically, the collapsing form of FSGS …
An 8-gene machine learning model improves clinical prediction of severe dengue progression
Background Each year 3–6 million people develop life-threatening severe dengue (SD).
Clinical warning signs for SD manifest late in the disease course and are nonspecific …
Clinical warning signs for SD manifest late in the disease course and are nonspecific …