During evolution, the cerebral cortex advances by increasing in surface and the introduction
of new cytoarchitectonic areas among which the prefrontal cortex (PFC) is considered to be …

Brain development is an extraordinarily complex process achieved through the spatially and
temporally regulated release of key patterning factors. In vitro neurodevelopmental models …

The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal
and glial cell types. Cortical neurons can be broadly categorized into two classes …

The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …

Human brain organoids provide unique platforms for modeling development and diseases
by recapitulating the architecture of the embryonic brain. However, current organoid …

Malformations of cortical development are a group of rare disorders commonly manifesting
with developmental delay, cerebral palsy or seizures. The neurological outcome is …

Brain organoids are self-assembled three-dimensional aggregates generated from
pluripotent stem cells with cell types and cytoarchitectures that resemble the embryonic …

Systematic analyses of spatiotemporal gene expression trajectories during organogenesis
have been challenging because diverse cell types at different stages of maturation and …

The cerebral cortex constitutes more than half the volume of the human brain and is
presumed to be responsible for the neuronal computations underlying complex phenomena …

Human accelerated regions (HARs) are the fastest-evolving regions of the human genome,
and many are hypothesized to function as regulatory elements that drive human-specific …