The Role of LFA-1 for the Differentiation and Function of Regulatory T Cells—Lessons Learned from Different Transgenic Mouse Models

T Klaus, A Wilson, M Fichter, M Bros, T Bopp… - International Journal of …, 2023 - mdpi.com
Regulatory T cells (Treg) are essential for the maintenance of peripheral tolerance. Treg
dysfunction results in diverse inflammatory and autoimmune diseases with life-threatening …

Variable CD18 expression in a 22‐year‐old female with leukocyte adhesion deficiency I: Clinical case and literature review

AV Bondarenko, OR Boyarchuk… - Clinical Case …, 2023 - Wiley Online Library
Key Clinical Message Partial leukocyte adhesion deficiency type 1 (LAD‐1) deficiency is
extremely rare condition with milder infectious manifestation and immune system imbalance …

Reduced CD18 levels drive regulatory T cell conversion into Th17 cells in the CD18hypo PL/J mouse model of psoriasis

K Singh, M Gatzka, T Peters, L Borkner… - The Journal of …, 2013 - journals.aai.org
Defective development and function of CD4+ CD25 high+ Foxp3+ regulatory T cells (Tregs)
contribute to the pathogenesis of psoriasis and other autoimmune diseases. Little is known …

Distinct Effects of Integrins αXβ2 and αMβ2 on Leukocyte Subpopulations during Inflammation and Antimicrobial Responses

S Jawhara, E Pluskota, W Cao, EF Plow… - Infection and …, 2017 - Am Soc Microbiol
Integrins αMβ2 and αXβ2 are homologous adhesive receptors that are expressed on many
of the same leukocyte populations and bind many of the same ligands. Although αMβ2 was …

Highlighting the problematic reliance on CD18 for diagnosing leukocyte adhesion deficiency type 1

S Levy-Mendelovich, E Rechavi, O Abuzaitoun… - Immunologic …, 2016 - Springer
Leukocyte adhesion deficiency type 1 (LAD-1) is an autosomal recessive primary
immunodeficiency, hallmarked by defective polymorphonuclear transmigration. It is caused …

Reduction of CD18 promotes expansion of inflammatory γδ T cells collaborating with CD4+ T cells in chronic murine psoriasiform dermatitis

M Gatzka, A Hainzl, T Peters, K Singh… - The Journal of …, 2013 - journals.aai.org
IL-17 is a critical factor in the pathogenesis of psoriasis and other inflammatory diseases.
The impact of γδ T cells, accounting for an important source of IL-17 in acute murine IL-23 …

Pyoderma gangrenosum with an underlying leukocyte adhesion deficiency type 1 (LAD-1) and pregnancy in the shade of COVID-19 epidemic: a patient and physician …

A Opalińska, A Burdacki, K Kwaśniak, K Pogoda… - Dermatology and …, 2021 - Springer
In the first part of this article, the anonymous patient diagnosed with leukocyte adhesion
deficiency type 1 (LAD-1) and pyoderma gangrenosum (PG) discusses her experience of …

Pediatric psoriasis

S Tolliver, AN Pepper, S Pothiawala… - Advances in Psoriasis: A …, 2021 - Springer
Psoriasis is a chronic multi-system inflammatory condition with an autoimmune component.
One-third to one-half of cases have onset in childhood. There are a variety of pediatric …

Deficiența de adeziune leucocitară (LAD)

L Andrieş, D Barba, V Surdu, M Pleşca - Imunodeficiențele primare în …, 2023 - ibn.idsi.md
Deficiența de aderență a leucocitelor (LAD–Leucocyte Adhesion Deficiency) prezintă o
imunodeficiență primară rară care face parte din grupa defectelor cantitative și …

Pediatric psoriasis

AN Pepper, S Pothiawala, NB Silverberg - Advances in Psoriasis: A …, 2014 - Springer
Psoriasis is a chronic multi-system inflammatory condition with an autoimmune component.
One-third to one-half of cases have onset in childhood. There are a variety of pediatric …