Triple artemisinin-based combination therapies for malaria–a new paradigm?

RW van der Pluijm, C Amaratunga, M Dhorda… - Trends in …, 2021 - cell.com
Recent gains in the fight against malaria are threatened by the emergence and spread of
artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong …

The threat of antimalarial drug resistance

B Hanboonkunupakarn, NJ White - Tropical diseases, travel medicine and …, 2016 - Springer
The battle between man and malaria has continued for thousands of years. Antimalarial
drugs are essential weapons to fight the disease, but their efficacy is threatened by drug …

Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

C Amaratunga, P Lim, S Suon, S Sreng… - The Lancet infectious …, 2016 - thelancet.com
Summary Background Artemisinin resistance in Plasmodium falciparum threatens to reduce
the efficacy of artemisinin combination therapies (ACTs), thus compromising global efforts to …

Immunogenicity of the RTS, S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised …

MT White, R Verity, JT Griffin, KP Asante… - The Lancet infectious …, 2015 - thelancet.com
Summary Background The RTS, S/AS01 malaria vaccine targets the circumsporozoite
protein, inducing antibodies associated with the prevention of Plasmodium falciparum …

Evidence of Plasmodium falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin-piperaquine open-label …

R Leang, WRJ Taylor, DM Bouth, L Song… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Western Cambodia is recognized as the epicenter of Plasmodium falciparum multidrug
resistance. Recent reports of the efficacy of dihydroartemisinin (DHA)-piperaquine (PP), the …

[PDF][PDF] WHO guidelines for malaria, 3 June 2022

World Health Organization - 2022 - apps.who.int
This document is a PDF generated from the WHO Guidelines for malaria hosted on the
MAGICapp online platform: https://app. magicapp. org/#/guideline/6287. Each time the …

[HTML][HTML] Persistent detection of Plasmodium falciparum, P. malariae, P. ovale curtisi and P. ovale wallikeri after ACT treatment of asymptomatic Ghanaian school …

B Dinko, MC Oguike, JA Larbi, T Bousema… - International Journal for …, 2013 - Elsevier
Two hundred and seventy four asymptomatic Ghanaian school-children aged 5 to 17 years
were screened for malaria parasites by examination of blood films. One hundred and fifty …

Treatment and prevention of malaria in children

EA Ashley, JR Poespoprodjo - The Lancet Child & Adolescent …, 2020 - thelancet.com
Malaria disproportionately affects children younger than 5 years. Falciparum malaria is
responsible for more than 200 000 child deaths per year in Africa and vivax malaria is well …

Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization

NJ White - Antimicrobial agents and chemotherapy, 2013 - Am Soc Microbiol
Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses
which were too low, particularly for high-risk groups such as young children and pregnant …

Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial

V Bigira, J Kapisi, TD Clark, S Kinara, F Mwangwa… - PLoS …, 2014 - journals.plos.org
Background Chemoprevention offers a promising strategy for prevention of malaria in
African children. However, the optimal chemoprevention drug and dosing strategy is unclear …