Hypoxia, a hallmark of solid tumors, determines the selection of invasive and aggressive
malignant clones displaying resistance to radiotherapy, conventional chemotherapy or …

Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …

abstract Despite significant research efforts, only a few treatment approaches have been
developed for hepatocellular carcinoma (HCC). In recent years, immune checkpoint …

Immune checkpoints include stimulatory and inhibitory checkpoint molecules. In recent
years, inhibitory checkpoints, including cytotoxic T lymphocyte–associated antigen 4 (CTLA …

Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Intense
efforts have been made to elucidate the pathogeny, but the molecular mechanisms of HCC …

Objectives To investigate the predictive value of quantifiable imaging and inflammatory
biomarkers in patients with hepatocellular carcinoma (HCC) for the clinical outcome after …

Immune checkpoint inhibition suggests promising progress for the treatment of advanced
hepatocellular carcinoma (HCC). However, the underlying cellular mechanisms remain …

Hepatocellular carcinoma (HCC) is the most common malignancy worldwide, and is
especially common in China. A total of 70%–80% of patients are diagnosed at an advanced …

With the recent approvals for the application of monoclonal antibodies that target the well-
characterized immune checkpoints, immune therapy shows great potential against both …