Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

Synthetic chemistry plays an indispensable role in drug discovery, contributing to hit
compounds identification, lead compounds optimization, candidate drugs preparation, and …

Spatially charting molecular cell types at single-cell resolution across the 3D volume is
critical for illustrating the molecular basis of brain anatomy and functions. Single-cell RNA …

The advancement of precision medicine in modern biomedicine has been significantly
propelled by the emergence of micro/nanorobots. The combination of micro/nanorobots and …

Peptide-based drug development for CNS disorders is challenged by poor blood-brain
barrier (BBB) penetrability of peptides. While acylation protractions (lipidation) have been …

Mono‐chemotherapy has significant side effects and unsatisfactory efficacy, limiting its
clinical application. Therefore, a combination of multiple treatments is becoming more …

Lysophosphatidylserine (lyso-PS) has emerged as yet another important signaling
lysophospholipid in mammals, and deregulation in its metabolism has been directly linked to …

MicroRNA (miRNA) delivery by extracellular vesicles (EVs) has recently inspired
tremendous developments in cancer treatments. However, hybridization between miRNA …

Conspectus Signaling lipids, such as the endocannabinoids, play an important role in the
brain. They regulate synaptic transmission and control various neurophysiological …

Light-sheet fluorescence microscopy (LSFM) combined with tissue clearing has emerged as
a powerful technology in drug discovery. LSFM is applicable to a variety of samples, from …