The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose
principal function is contraction. However, this cell displays remarkable plasticity and can …

The vast diversity of cellular types and behaviours is mainly the result of combinatorial
interactions between a limited number of transcription factors and cellular signalling …

Serum response factor (SRF) is a highly conserved and widely expressed, single copy
transcription factor that theoretically binds up to 1,216 permutations of a 10-base pair cis …

The association of transcriptional coactivators with sequence-specific DNA-binding proteins
provides versatility and specificity to gene regulation and expands the regulatory potential of …

MicroRNAs (miRNAs) are genomically encoded small RNAs that hybridize with messenger
RNAs, resulting in degradation or translational inhibition of targeted transcripts. The …

In the postnatal vasculature, fully differentiated and quiescent vascular smooth muscle cells
(VSMCs) in a" contractile" phenotype are required for the normal regulation of vascular tone …

The association of transcriptional coactivators with DNA-binding proteins provides an
efficient mechanism to expand and modulate genetic information encoded within the …

Collective cell migration drives tissue remodeling during development, wound repair and
metastatic invasion. The physical mechanisms by which cells move cohesively through …

The popularity of Drosophila melanogaster as a model for understanding eukaryotic biology
over the past 100 years has been accompanied by the development of numerous tools for …

Myocardin and the myocardin-related transcription factors (MRTFs) MRTF-A and MRTF-B
are coactivators for serum response factor (SRF), which regulates genes involved in cell …