Single-cell sequencing to multi-omics: Technologies and applications
X Wu, X Yang, Y Dai, Z Zhao, J Zhu, H Guo, R Yang - Biomarker Research, 2024 - Springer
Cells, as the fundamental units of life, contain multidimensional spatiotemporal information.
Single-cell RNA sequencing (scRNA-seq) is revolutionizing biomedical science by …
Single-cell RNA sequencing (scRNA-seq) is revolutionizing biomedical science by …
Tools and strategies for analysis of genome-wide and gene-specific DNA methylation patterns
DNA methylation is a stable epigenetic mechanism that has important roles in the normal
function of a cell and therefore also in disease etiology. Accurate measurements of normal …
function of a cell and therefore also in disease etiology. Accurate measurements of normal …
Detection of significantly differentially methylated regions in targeted bisulfite sequencing data
Motivation: Bisulfite sequencing is currently the gold standard to obtain genome-wide DNA
methylation profiles in eukaryotes. In contrast to the rapid development of appropriate pre …
methylation profiles in eukaryotes. In contrast to the rapid development of appropriate pre …
Light Remodels Lipid Biosynthesis in Nannochloropsis gaditana by Modulating Carbon Partitioning between Organelles
The seawater microalga Nannochloropsis gaditana is capable of accumulating a large
fraction of reduced carbon as lipids. To clarify the molecular bases of this metabolic feature …
fraction of reduced carbon as lipids. To clarify the molecular bases of this metabolic feature …
DMAP: differential methylation analysis package for RRBS and WGBS data
PA Stockwell, A Chatterjee, EJ Rodger… - …, 2014 - academic.oup.com
Motivation: The rapid development of high-throughput sequencing technologies has
enabled epigeneticists to quantify DNA methylation on a massive scale. Progressive …
enabled epigeneticists to quantify DNA methylation on a massive scale. Progressive …
Methodological aspects of whole-genome bisulfite sequencing analysis
The combination of DNA bisulfite treatment with high-throughput sequencing technologies
has enabled investigation of genome-wide DNA methylation beyond CpG sites and CpG …
has enabled investigation of genome-wide DNA methylation beyond CpG sites and CpG …
Comparison and quantitative verification of mapping algorithms for whole-genome bisulfite sequencing
G Kunde-Ramamoorthy, C Coarfa… - Nucleic acids …, 2014 - academic.oup.com
Coupling bisulfite conversion with next-generation sequencing (Bisulfite-seq) enables
genome-wide measurement of DNA methylation, but poses unique challenges for mapping …
genome-wide measurement of DNA methylation, but poses unique challenges for mapping …
HMM-DM: identifying differentially methylated regions using a hidden Markov model
DNA methylation is an epigenetic modification involved in organism development and
cellular differentiation. Identifying differential methylations can help to study genomic regions …
cellular differentiation. Identifying differential methylations can help to study genomic regions …
Bicycle: a bioinformatics pipeline to analyze bisulfite sequencing data
O Graña, H López-Fernández, F Fdez-Riverola… - …, 2018 - academic.oup.com
High-throughput sequencing of bisulfite-converted DNA is a technique used to measure
DNA methylation levels. Although a considerable number of computational pipelines have …
DNA methylation levels. Although a considerable number of computational pipelines have …
ZASP interacts with the mechanosensing protein Ankrd2 and p53 in the signalling network of striated muscle
ZASP is a cytoskeletal PDZ-LIM protein predominantly expressed in striated muscle. It forms
multiprotein complexes and plays a pivotal role in the structural integrity of sarcomeres …
multiprotein complexes and plays a pivotal role in the structural integrity of sarcomeres …