Symptoms of Parkinson's disease arise due to neuronal loss in multiple brain regions,
especially dopaminergic neurons in the substantia nigra pars compacta. Current therapies …

The discovery of causative genetic mutations in affected family members has historically
dominated our understanding of neurodegenerative diseases such as Alzheimer's disease …

Parkinson's disease (PD) is a common neurodegenerative disorder caused by genetic and
environmental factors that results in degeneration of the nigrostriatal dopaminergic pathway …

Background: Microarray technologies have identified imbalances in the expression of
specific genes and biological pathways in Alzheimer's disease (AD) brains. However, there …

MicroRNA (miRNA) misregulation in peripheral blood has been linked to Parkinson disease
(PD) but its role in the disease progression remains elusive. We performed an explorative …

The etiology of Parkinson's disease is largely unknown. Genome-wide transcriptomic
studies in bulk brain tissue have identified several molecular signatures associated with the …

Repulsive guidance molecule member a (RGMa) is a membrane-associated or released
guidance molecule that is involved in axon guidance, cell patterning, and cell survival. In our …

Sporadic amyotrophic lateral sclerosis (sALS) is a severe neurodegenerative disease that
causes progressive motor neuron death. Although the etiology of sALS remains unknown …

Parkinson's disease (PD)—classically characterized by severe loss of dopaminergic
neurons in the substantia nigra pars compacta—has a caudal‐rostral progression …

Background Systemic lupus erythematosus (SLE) is a genetically complex rheumatic
disease characterized by heterogeneous clinical manifestations of unknown etiology …