The gut microbiome is critical in providing resistance against colonization by exogenous
microorganisms. The mechanisms via which the gut microbiota provide colonization …

Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of
bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal …

The facultative human pathogen Vibrio cholerae can be isolated from estuarine and aquatic
environments. V. cholerae is well recognized and extensively studied as the causative agent …

Analysis of genes required for host infection will provide clues to the drivers of evolutionary
fitness of pathogens like Vibrio cholerae, a mounting threat to global heath. We used …

Enteric bacteria are resistant to the bactericidal effects of intestinal bile, but these resistance
mechanisms are not completely understood. It is becoming increasingly apparent that …

To cause the diarrheal disease cholera, Vibrio cholerae must effectively colonize the small
intestine. In order to do so, the bacterium needs to successfully travel through the stomach …

The transmembrane transcriptional activators ToxR and TcpP modulate expression of Vibrio
cholerae virulence factors by exerting control over toxT, which encodes the cytoplasmic …

Bacterial pathogens have coevolved with humans in order to efficiently infect, replicate
within, and be transmitted to new hosts to ensure survival and a continual infection cycle. For …

Commensal and pathogenic bacteria must deal with many different stress conditions to
survive in and colonize the human gastrointestinal tract. One major challenge that bacteria …

The causative agent of cholera, Vibrio cholerae, regulates its diverse virulence factors to
thrive in the human small intestine and environmental reservoirs. Among this pathogen's …