Parkin activates innate immunity and promotes antitumor immune responses

M Perego, M Yeon, E Agarwal, AT Milcarek… - The Journal of Clinical …, 2024 - jci.org
The activation of innate immunity and associated interferon (IFN) signaling have been
implicated in cancer, but the regulators are elusive and links to tumor suppression remain …

Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway

Q Su, J Wang, J Ren, Q Wu, K Chen, K Tu… - Acta Pharmacologica …, 2024 - nature.com
Parkin (PARK2) deficiency is frequently observed in various cancers and potentially
promotes tumor progression. Here, we showed that Parkin expression is downregulated in …