Efficacy and safety of JAK inhibitors in rheumatoid arthritis: update for the practising clinician

Z Szekanecz, MH Buch, C Charles-Schoeman… - Nature Reviews …, 2024 - nature.com
Janus kinase (JAK) inhibitors, including tofacitinib, baricitinib, upadacitinib and filgotinib, are
increasingly used in the treatment of rheumatoid arthritis (RA). There has been debate about …

Risk of major adverse cardiovascular events with tofacitinib versus tumour necrosis factor inhibitors in patients with rheumatoid arthritis with or without a history of …

C Charles-Schoeman, MH Buch… - Annals of the …, 2023 - ard.bmj.com
Objectives Evaluate risk of major adverse cardiovascular events (MACE) with tofacitinib
versus tumour necrosis factor inhibitors (TNFi) in patients with rheumatoid arthritis (RA) with …

JAK inhibition in Juvenile idiopathic arthritis (JIA): better understanding of a promising therapy for refractory cases

I Melki, ML Frémond - Journal of Clinical Medicine, 2023 - mdpi.com
Juvenile idiopathic arthritis (JIA) is a heterogeneous group of diseases with probably
differential underlying physiopathology. Despite the revolutionary era of biologics, some …

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update

JS Smolen, RBM Landewé, SA Bergstra… - Annals of the …, 2023 - ard.bmj.com
Objectives To provide an update of the EULAR rheumatoid arthritis (RA) management
recommendations addressing the most recent developments in the field. Methods An …

Efficacy and safety of dose escalation of tofacitinib in refractory anti-MDA5 antibody-positive dermatomyositis

T Ida, S Furuta, A Takayama, J Tamura, Y Hayashi… - RMD open, 2023 - rmdopen.bmj.com
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive
dermatomyositis (MDA5-DM) is frequently complicated with rapidly progressive-interstitial …

Therapeutic advances in rheumatoid arthritis

P Brown, AG Pratt, KL Hyrich - bmj, 2024 - bmj.com
Rheumatoid arthritis (RA) is one of the most common immune mediated inflammatory
diseases. People with rheumatoid arthritis present with pain, swelling, and stiffness that …

Janus kinase inhibitors in rheumatoid arthritis: An update on the efficacy and safety of tofacitinib, baricitinib and upadacitinib

R Harrington, P Harkins, R Conway - Journal of Clinical Medicine, 2023 - mdpi.com
Janus kinase inhibitors (JAKis) are the most recent new drug class to arrive to the market for
rheumatoid arthritis (RA) treatment. While they have proven to be a very effective treatment …

[HTML][HTML] Mitochondrion-NLRP3 inflammasome activation in macrophages: A novel mechanism of the anti-inflammatory effect of Notopterygium in rheumatoid arthritis …

X Liu, X Chen, C Zhang, M Huang, H Yu… - Biomedicine & …, 2023 - Elsevier
Objective The mechanism by which Notopterygium (NE) regulates the nucleotide‐binding,
oligomerization domain (NOD)‐like receptor family and pyrin domain-containing 3 (NLRP3) …

Safety of the JAK and TNF inhibitors in rheumatoid arthritis: real world data from the Hong Kong Biologics Registry

CC Mok, H So, CW Yim, CH To, WN Lao… - …, 2024 - academic.oup.com
Objectives To compare the incidence of major adverse cardiovascular events (MACEs),
cancer and infective complications in RA patients using Janus kinase (JAKis) and TNF …

[HTML][HTML] JAK Inhibitors in Rheumatoid Arthritis: Immunomodulatory Properties and Clinical Efficacy

K Kiełbowski, P Plewa, AW Bratborska… - International Journal of …, 2024 - mdpi.com
Rheumatoid arthritis (RA) is a highly prevalent autoimmune disorder. The pathogenesis of
the disease is complex and involves various cellular populations, including fibroblast-like …