Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Alcohols are abundant with versatile structural variety and have ample use as pivotal
functional groups in numerous organic processes. Because of their frequent occurrence in …

Chiral allylic alcohols are highly prized in synthetic chemistry due to their versatile reactivity
stemming from both alkenyl and hydroxyl functionalities. While the Nozaki–Hiyama–Kishi …

The primary greenhouse gas is carbon dioxide (CO2), which also serves as an excellent C1
building block for the synthesis of heterocyclic compounds. The preparation and …

The generation of radical intermediates via SET-mediated deoxygenation of activated
alcohol derivatives is desirable, as alcohols can be utilized in various radical-mediated …

The use of alcohol feedstock as a coupling partner in cross-coupling reactions offers an
extraordinary potential for the efficient synthesis of Csp3-rich complex molecular scaffolds …

The selective cross-coupling of two alkyl electrophiles to construct complex molecules
remains a challenge in organic synthesis. 1, 2 Known reactions are optimized for specific …

In pharmaceutical discovery, the “magic methyl” effect describes a substantial improvement
in the pharmacological properties of a drug candidate with the incorporation of methyl …

The cross-coupling of aryl bromides with alkenes can provide access to diverse
combinatorial chemical space. Two-component couplings between these partners are well …

Tertiary alkylamines are privileged structural motifs widely present in natural products,
pharmaceutical agents, and bioactive molecules, and their efficient synthesis has been a …