The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

In classical G-protein-coupled receptor (GPCR) activation, GPCRs couple to a variety of
heterotrimeric G proteins on the membrane and then activate downstream signaling …

The renin-angiotensin system is a central component of the physiological and pathological
responses of cardiovascular system. Its primary effector hormone, angiotensin II (ANG II), not …

The importance of the renin angiotensin aldosterone system in cardiovascular physiology
and pathophysiology has been well described whereas the detailed molecular mechanisms …

Abstract Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …

Background—Whether biomechanical force on the heart can induce exosome secretion to
modulate cardiovascular function is not known. We investigated the secretion and activity of …

The classical idea that G‐protein‐coupled receptors (GPCRs) function as monomeric
entities has been unsettled by the emerging concept of GPCR dimerization. Recent findings …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

G protein–coupled receptor (GPCR) oligomers have been proposed to play critical roles in
cell signaling, but confirmation of their existence in a native context remains elusive, as no …

For many years seven transmembrane domain G protein-coupled receptors (GPCRs) were
thought to exist and function exclusively as monomeric units. However, evidence both from …